Vanadium Helps to Support:

· Healthy sugar levels*

· Healthy cellular replication in the body*

· Strong Bones and teeth*

 

Supplement Facts
Serving Size: 1 Tablespoon         Servings Per Container: 39
	Amount Per Serving	% Daily Value
Vanadium (as vanadyl sulfate)	100 mg	N/A
Ingredients: Purified Water, vanadyl sulfate, ozone. Directions for Use: Adults: 1 tablespoon daily. It is recommended that before starting any new mineral or supplementation program, you first consult your health care professional. Do not use if tamper evident seal is either missing or broken. Keep out of reach of children. Shake well before using Refrigerate after opening

Vanadium is an ultra-trace mineral found in the human diet and the human body. In its natural form, Vanadium is very colorful and is found in very small amounts in a wide variety of foods, including seafoods, cereals, mushrooms, parsley, corn, soy, and gelatin. It is a metallic element that exists in several oxidation states, including +2, +3, +4, and even +5. In living matter, Vanadium is found mainly as the tetravalent vanadyl cation and the pentavalent vanadate form.

Currently, Vanadium is a mineral that is being explored to further understand its possible role in promoting human health. In research anamils, a diet deficient in Vanadium has lead to symptoms including growth retardation, bone deformities, and infertility. Vanadium also is suggested to possibly play a role in building healthy bones and teeth.

Parker Hughes Institute scientists develop 24 new drugs containing metal

Vanadium effective in fighting cancer cells

May 3, 2000, Saint Paul, Minn. ( In a systematic effort to develop effective drugs with a broad spectrum and potent anti-cancer activity, researchers at the St. Paul, Minn.-based Parker Hughes Institute have developed 24 new drugs containing the metal vanadium. The results of this research are published in this months issue of Clinical Cancer Research, the official scientific journal of the American Association of Cancer Research.

These novel drugs were effective against 14 of 14 different cancer cell lines as well as cancer cells taken directly from patients. Targeted cancer cells included those of breast cancer, prostate cancer, testicular cancer, ovarian cancer, colon cancer, brain tumors, leukemia and lymphoma. These new anti-cancer drugs work by causing the cancer cells to commit suicide (or apoptosis) within 4 to 24 hours.

These drugs are now being tested in animal safety studies to identify those that have the best therapeutic index.

References Narla RK, Dong Y, DÕCruz OJ, Navara C, Uckun FM. Bis (4,7-dimethyl-1, 10-phenanthroline) sulfatooxovanadium as a novel apoptosis-inducing anticancer agent. Clinical Cancer Research, 6:1546-56, 2000.

Ghosh P, DÕCruz OJ, Narla RK, Uckun FM. Apoptosis-inducing vanadocene compounds against human testicular cancer. Clinical Cancer Research, 6:1536-45, 2000.

The Parker Hughes Institute http://www.parkerhughes.org/, located in Roseville, Minnesota, is a non-profit research organization dedicated to combating cancer, AIDS, and diseases of the immune system.

Vanadium has not yet proven to be an essential mineral for humans, and researchers caution that long-term safety of large amounts of Vanadium ingestion remains unknown. The optimal intake of Vanadium is unknown and there is no RDA. If Vanadium turns out to be essential for humans, the estimated requirement would most likely be less than 10 micrograms per day.

Minerals for Life™ Vanadium is a liquid dietary supplement of the electrically charged ion particle Vanadium. Eniva® uses forms of minerals that thoroughly activate by ionization in pure OHM™ water, yielding the monatomic Vanadium equivalent, as shown as "Vanadium" in the "Supplement Facts" panel. A solution yields the smallest particles the size of atoms, ions, or small molecules, whereas colloidal dispersions contain large clusters of particles. The purer the water the more efficiently minerals are activated into their electrically charged ionic state.

Eniva® uses OHM™ water (multi-step purified water) in a unique proprietary process at Eniva's government-inspected-and-certified manufacturing facility, yielding ionically dislodged monatomic (Solutomic™) ions in sparkling clear solutions for quicker absorption than tablets or capsules which must first dissolve in the digestive system before being absorbed.

This product has been structurally enhanced with Negative Field Activation™. It has been treated with a proprietary negative magnetic field design at over 1,000 times the strength of the earth's own magnetic field.

Adult Directions
Take 1 tablespoon daily.

Caution
It is highly recommended that Vanadium supplementation be used for only a short period of time unless under the direct supervision of a medical professional. It is recommended that those with manic depression and mood disorders, or on MAO inhibitor medications avoid Vanadium supplementation.
Do not consume if tamper resistant seal is broken or missing. Keep cap tightly closed and out of reach of children. Not intended for children under 14 years of age. Not for pregnant or lactating women. First consult with your physician before starting this or new mineral or supplement program.

 

* This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Scientific Reference
Aharon Y, Mevorach M, Shamoon H. Vanadyl sulfate does not enhance insulin action in patients with type 1 diabetes. Diabetes Care 1998;21:2194 [letter].

Balasubramanyam M, Mohan V. Orally active insulin mimics: where do we stand now? J Biosci. 2001 Sep;26(3):383-90. Review PMID: 11568484 [PubMed - indexed for MEDLINE]

Boden G, Chen X, Ruiz J, et al. Effects of vanadyl sulfate on carbohydrate and lipid metabolism in patients with non-insulin-dependent diabetes mellitus. Metabolism 1996;45:1130–5.

Cam MC, Brownsey RW, Rodrigues B, McNeill JH. Lack of in vivo effect of vanadium on GLUT4 translocation in white adipose tissue of streptozotocin-diabetic rats. Metabolism. 2001 Jun;50(6):674-80.

Chakraborty A, Ghosh R, Roy K, et al. Vanadium: a modifier of drug metabolizing enzyme patterns and its critical role in cellular proliferation in transplantable murine lymphoma. Oncology 1995;52:310–4.

D'Cruz OJ, Uckun FM. Vanadocene-Mediated in Vivo Male Germ Cell Apoptosis. Toxicology and Applied Pharmacology, 166(3):186-95, 2000.

Ding W, Hasegawa T, Hosaka H, Peng D, Takahashi K, Seko Y. Effect of long-term treatment with vanadate in drinking water on KK mice with genetic non-insulin-dependent diabetes mellitus. Biol Trace Elem Res. 2001 May;80(2):159-74. PMID: 11437181 [PubMed - indexed for MEDLINE]

Ekmekcioglu C, Prohaska C, Pomazal K, Steffan I, Schernthaner G, Marktl W. Concentrations of seven trace elements in different hematological matrices in patients with type 2 diabetes as compared to healthy controls. Biol Trace Elem Res. 2001 Mar;79(3):205-19.

Ghosh P, D’Cruz OJ, Narla RK, Uckun FM. Apoptosis-inducing vanadocene compounds against human testicular cancer. Clinical Cancer Research, 6:1536-45, 2000. Inorg Chem. 2001 Aug 27;40(18):4686-90.

Kordowiak AM, Dudek B, Grybos R. Influence of sodium bis(oxalato)oxovanadate(IV) on phospholipids in liver Golgi fractions from control and streptozotocin-diabetic rats. Comp Biochem Physiol C Toxicol Pharmacol. 2000 Jan;125(1):11-6.

Lapenna D, Ciofani G, Bruno C, Pierdomenico SD, Giuliani L, Giamberardino MA, Cuccurullo F. Vanadyl as a catalyst of human lipoprotein oxidation. Biochem Pharmacol. 2002 Feb 1;63(3):375-80.

Li H, Wei Q. Conformation changes in brain calcineurin in diabetic rats with or without treatment with vanadyl sulfate. IUBMB Life. 2001 Jun;51(6):373-6.

Marita AR, Anilkumar KL. Effect of vanadate on glycogen synthesis in dexamethasone-treated 3T3 adipocytes: evidence for a novel insulin sensitizing action. Diabetes Obes Metab. 2001 Aug;3(4):271-8.

Martin G, Rand J. Current understanding of feline diabetes: part 2, treatment. J Feline Med Surg. 2000 Mar;2(1):3-17. Review.

Melchior M, Rettig SJ, Liboiron BD, Thompson KH, Yuen VG, McNeill JH, Orvig C. Insulin-enhancing vanadium(III) complexes.

Mohammad A, Bhanot S, McNeill JH. In vivo effects of vanadium in diabetic rats are independent of changes in PI-3 kinase activity in skeletal muscle. Mol Cell Biochem. 2001 Jul;223(1-2):103-8.

Narla RK, Dong Y, D’Cruz OJ, Navara C, Uckun FM. Bis (4,7-dimethyl-1, 10-phenanthroline) sulfatooxovanadium as a novel apoptosis-inducing anticancer agent. Clinical Cancer Research, 6:1546-56, 2000.

Naylor GJ. Vanadium and manic depressive psychosis. Nutritional Health 1984;3:79–85 [review].

Semiz S, Orvig C, McNeill JH. Effects of diabetes, vanadium, and insulin on glycogen synthase activation in Wistar rats. Mol Cell Biochem. 2002 Feb;231(1-2):23-35.

Shinde UA, Mehta AA, Goyal RK. Effect of chronic treatment with Bis(maltolato)oxovanadium (IV) in rat model of non-insulin-dependent-diabetes. Indian J Exp Biol. 2001 Sep;39(9):864-70.

Thompson KH, Tsukada Y, Xu Z, Battell M, McNeill JH, Orvig C. Influence of chelation and oxidation state on vanadium bioavailability, and their effects on tissue concentrations of zinc, copper, and iron. Biol Trace Elem Res. 2002 Apr;86(1):31-44.

Wang J, Yuen VG, McNeill JH. Effect of vanadium on insulin and leptin in Zucker diabetic fatty rats. Mol Cell Biochem. 2001 Feb;218(1-2):93-6.

Willsky GR, Goldfine AB, Kostyniak PJ, McNeill JH, Yang LQ, Khan HR, Crans DC. Effect of vanadium(IV) compounds in the treatment of diabetes: in vivo and in vitro studies with vanadyl sulfate and bis(maltolato) oxovandium(IV). J Inorg Biochem. 2001 May;85(1):33-42.

Urban J, Antonowicz-Juchniewicz J, Andrzejak R. [Vanadium: threat and hope] Med Pr. 2001;52(2):125-33. Review. Polish.