ATP Plus, Fibromyalgia Chronic Fatigue Gulf War Syndrome Treatment Clinically proven to work

This product contains a clinically tested and patented form of D-Ribose. In university studies it has been shown to improve cardiac function and symptoms of Fibromyalgia. It provides patented D-Ribose (a cellular regulator of ATP energy production) which is clinically proven to restore cardiac function and improve the quality of life for individuals struggling with the effects of cardiovascular disease, including congestive heart failure.*

Eniva ATP-Plus is the answer. It provides your body with a patented form of D-ribose, the most fundamental source of energy your body can have. Ribose is what your body uses to naturally build its energy stores and taking Eniva ATP-PLUS helps your body quickly replace energy levels that have been depleted by hard work, exercise, or health challenges. Please read on to learn how ATP-PLUS can help your body replace lost energy and why it is so important to overall health and quality of life.

" Ribose is so important to the metabolism of energy in the body that it actually regulates the entire process of energy production and synthesis."

The core research and strength of ATPIus is in a compound called D-Ribose. This is a carbohydrate with amazing properties. It is fundamental to the existence of all living cells and functions as the sole regulator in the production of ATP (adenosine‑triphosphate), the most basic source of all cellular energy. It is the carbohydrate backbone of genetic material and is also core to the production of many essential metabolic compounds.

One key aspect of D-Ribose lies in its action at low oxygen conditions. When the body's oxygen‑carrying capacity decreases, significant health conditions can arise. This is the basis for tissue damage in various medical challenges, including cardiovascular health, muscle and energy health, muscle recovery, and many other medically related challenges. D‑Ribose aids the body to produce cellular energy in low oxygen conditions more efficiently, allowing the body more energy for recovery, delivery

Our bodies rely on the compound adenosine triphosphate (ATP) as the source of virtually all its energy requirements. ATP belongs to a class of compounds known as adenine nucleotides and our bodies rely on these compounds as the energy source needed to perform every bodily function. ATP keeps hearts beating, muscles contracting and cells functioning. Without ATP our tissues would simply stop working. High levels of cellular energy are required to keep tissues running at their peak performance.

Food and oxygen are the fuels used by the body to stoke the furnace of energy turnover. As long as there is a sufficient supply of these critical fuels, energy levels are maintained in the body and tissues function normally. However, simply by living our normal daily lives we routinely run into situations when these fuels are not adequately available. For example, disease, strenuous labor or high-intensity exercise all increase our demand for oxygen, reduce its availability to our tissues or disrupt normal energy metabolism. When we use oxygen faster than it can be supplied, our body cannot generate energy fast enough and energy reserves become depleted.

A reduction in the body's total energy may lead to a variety of physiological concerns including fatigue, muscle soreness, stiffness, tissue dysfunction or even total tissue failure if the energy is completely depleted by a lack of oxygen.1-3 Even when oxygen levels return to normal, it may take several days for the energy pool to recover.4-7 Studies have shown that, following repeated strenuous exercise, it may take three days for energy levels to be restored to normal, and in cases of heart disease or other diseases that reduce the flow of blood to tissue (a condition called ischemia) energy levels may never fully normalize.

Tissue energy pools are adequately as long as oxygen is readily available. When pools are reduced, however, our bodies need to rebuild energy supplies through a mechanism known as de novo synthesis. In addition, at the same time energy pools are being stressed, the body attempts to salvage any remaining energy compounds before they are used up. These salvage pathways are also active in every cell in the body and help keep the energy pools from being used up too quickly.

"Eniva ATPPlusTM is the most fundamental energy supplement you can give your body to maintain healthy levels of cellular energy pools."

Both the de novo (new) and salvage pathways are regulated by ribose.8-11 If ribose is not present in the tissue, or is not present in a sufficient amount to drive the energy pathways, energy levels cannot be re-supplied. Ribose is the most fundamental energy compound available for rebuilding energy levels during and after physiologic stress.

Normal Levels of ATP(cellular energy) are Needed to Preserve Cell and Tissue Health

ATP(cellular energy) is critically important to the life of every cell. Each cell contains a limited supply of ATP needed to perform necessary functions. For example, to maintain its cell wall integrity and salt balance, cells need fully charged pools of ATP. ATP provides the energy used by the cell to move electrolytes across the cell membrane, both in and out of the cell. In addition, the supplies of ATP are necessary to lubricate the action of this movement.12-14

Synthesis of important cellular compounds, such as proteins, is also dependent on maintaining healthy pools of ATP within the cell. ATP is used to energize the metabolism of many critical cellular compounds and depletion of ATP pools contributes to the breakdown of these metabolic processes.

"Energy and cardiovascular health are top reasons consumers buy nutritional supplements or functional foods and beverages."

Tissues that are made up of groups of cells are also heavily dependent ATP concentration. In muscle, for example, ATP fuels contraction and relaxation. In heart muscle the effect of ATP on relaxation is critically important. During the relaxation phase of the heartbeat, known as diastolic phase, calcium ions are pumped out of the cell allowing the heart to fully relax. Full relaxation is necessary to allow the chambers of the heart to fill with blood to be pumped during the next heartbeat. Healthy levels of ATP pools are critical to maintaining healthy cardiac diastolic function.1,3,4,15-19

Short of cell or tissue death, even the most strenuous exercise or disease will not fully deplete ATP pools. There will always be enough ATP preserved in cells to allow muscles to contract, lungs to fill and the heart to pump. However, depletion of ATP pools in cells and tissue can have a dramatic effect on cellular integrity, electrolyte balance, normal cellular metabolism and tissue function. Keeping ATP pools fully restored is critical in keeping cells and tissues healthy and functioning normally.

Adenosine 5'-triphosphate (ATP) is a purine nucleotide found in every cell of the human body. In addition to its well established role in cellular metabolism, extracellular ATP and its breakdown product adenosine, exert pronounced effects in a variety of biological processes including neurotransmission, muscle contraction, cardiac function, platelet function, vasodilatation and liver glycogen metabolism. These effects are mediated by both P1 and P2 receptors. A cascade of ectonucleotidases plays a role in the effective regulation of these processes and may also have a protective function by keeping extracellular ATP and adenosine levels within physiological limits.

In recent years several clinical applications of ATP and adenosine have been reported. In anaesthesia, low dose adenosine reduced neuropathic pain, hyperalgesia and ischaemic pain to a similar degree as morphine or ketamine. Postoperative opioid use was reduced. During surgery, ATP and adenosine have been used to induce hypotension. In patients with haemorrhagic shock, increased survival was observed after ATP treatment. In cardiology, ATP has been shown to be a well tolerated and effective pulmonary vasodilator in patients with pulmonary hypertension. Bolus injections of ATP and adenosine are useful in the diagnosis and treatment of paroxysmal supraventricular tachycardias. Adenosine also allowed highly accurate diagnosis of coronary artery disease. In pulmonology, nucleotides in combination with a sodium channel blocker improved mucociliary clearance from the airways to near normal in patients with cystic fibrosis. In oncology, there are indications that ATP may inhibit weight loss and tumour growth in patients with advanced lung cancer. There are also indications of potentiating effects of cytostatics and protective effects against radiation tissue damage. Further controlled clinical trials are warranted to determine the full beneficial potential of ATP, adenosine and uridine 5'-triphosphate

Ribose is made naturally in our bodies by converting the simple sugar glucose into ribose. The ribose, once formed, can be used by cells to drive various methods of energy metabolism. However most tissues in the body, including the heart and muscles, cannot produce ribose fast enough to quickly restore energy levels once they have been depleted.

Ribose is synthesized in the body by a metabolic pathway called the pentose phosphate pathway. In heart, muscle and several other tissues the pentose phosphate pathway is slow and inefficient. In these tissues, certain important enzymes used to push glucose metabolism down the pentose phosphate pathway are lacking. These tissues prefer to use glucose to fuel ATP turnover and are reluctant to promote ribose synthesis. As a result, when ribose is required to re-supply ATP pools the process is sluggish. Providing supplemental ribose to these tissues significantly increases their ability to normalize ATP pools once they have been reduced or depleted.8,20,21

A large body of scientific evidence proves that administering ribose to tissue that has been stressed by strenuous work, high-intensity exercise or ischemia (low oxygen) significantly improves the ability of the tissue to rebuild the supply of ATP and adenine nucleotides.1,22-31 Ribose is easily absorbed into the blood and is taken up selectively by all tissues working to restore energy supplies.32,33

"ATPPlusTM stands alone in its ability to deliver a real, natural, demonstrable, safe and patent protected benefit to health conscious consumers."

But what constitutes strenuous work or high-intensity exercise? For each individual the parameters defining these conditions vary. For trained athletes, high-intensity exercise may be defined as training for a marathon, preparing for a triathlon event, or participating in two-a-day football practice workouts. For someone leading a more sedentary life, however, strenuous work may include everyday tasks such as raking the leaves, cutting the lawn or going for walks. And, for older individuals and those recovering or dealing with health challenges, the definition may be narrowed ever further.

In addition, fatigue, muscle soreness, increased cramping, delayed muscle recovery and reduced tissue function are all possible conditions that may result from prolonged depletion of tissue energy stores. In broad segments of the population, these conditions may be sufficient to significantly affect exercise tolerance and quality of life.

Athletes using ribose as a nutritional sports supplement should not expect sudden bursts of speed or immediate gains in power output. They should expect, however, that because tissue energy stores recover more quickly from a strenuous workout, the physiological condition of their muscles will improve. As shown by a recent publication, this enhanced recovery translates to greater gains over time.34

Those less conditioned should expect an even more immediate response. Taking ribose before and after a workout or strenuous physical activity reduces muscle soreness, lowers fatigue, improves recovery and enhances exercise tolerance. In short, supplementing with ATPPlusTM allows one to do more work, or exercise harder, with less discomfort.

There is no energy supplement currently on the market with the proven effectiveness of the D-ribose in Eniva's ATPPlusTM. The biochemical and physiological effects of this important ingredient have been investigated in both human and animal studies reported in over 100 peer-reviewed scientific publications.

The D-ribose used in Eniva's ATP-PlusTM is made by converting glucose, or corn sugar, into ribose by fermentation processes designed to meet the rigid standards of food and nutraceutical production. In 2002, following almost three years of laboratory, animal and human clinical studies, an expert panel affirmed that the ribose used in ATP-PlusTM is Generally Regarded as Safe (GRAS). Both the safety and efficacy of the D-ribose used in ATP-PlusTM are well established.

There are over 20 issued and pending patents protecting the use of this specific from of D-ribose over a broad array of medical and nutritional applications.

The D-Ribose used in ATPlus is
protected by patent protection covering a broad range of nutritional and
pharmaceutical uses for ribose. These include such things as:
a) use of ribose in cardiac diagnosis b) energy enhancement
c) use for the prevention of muscle soreness, stiffness and cramping d) use to treat ischemic tissue e) use to treat fibromyalgia
U.S. patent number 6,159,942 covers the oral use of ribose as an energy enhancing supplement when taken alone or in combination with other ingredients in drinks, energy bars, dietary supplements or other food and nutrition products.
U.S. patent number 6,159,943 covers the use of ribose for the prevention of muscle soreness and cramping following muscle over work or in cases of restricted circulation.
U.S. patents 4,719,201 and 4,605,644 cover the use of ribose alone or in combination with adenine for treating ischemic tissue.
Additional U.S. patents cover the use of ribose to unmask hibernating myocardium and aid in perfusion imaging diagnosis, respectively.
In addition, three patent applications,
including use of ribose in treatment of fibromyalgia, have been allowed in the United Kingdom and several are filed internationally under the Patent Cooperation Treaty designating all treaty countries.
*There is no known adverse reaction between D-ribose and any medications.


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