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Colon Health | ||||||
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*Vanadium, Calcium Vitamin D & CancerParker
Hughes Institute scientists develop 24 new drugs containing metal
Calcium & Cancer Can colon cancer incidence and death rates be reduced with calcium and vitamin D? Garland CF, Garland FC, Gorham ED. Am J Clin Nutr. 1991 Jul;54(1 Suppl):193S-201S.Department of Community and Family Medicine, University of California, San Diego, La Jolla 92093-0607. It was proposed in 1980 that vitamin D and calcium could reduce the risk of colon cancer. This assertion was based on the decreasing gradient of mortality rates from north to south, suggesting a mechanism related to a favorable influence of ultraviolet-induced vitamin D metabolites on metabolism of calcium. A 19-y prospective study of 1954 Chicago men found that a dietary intake of greater than 3.75 micrograms vitamin D/d was associated with a 50% reduction in the incidence of colorectal cancer, whereas an intake of greater than or equal to 1200 mg Ca/d was associated with a 75% reduction. Clinical and laboratory studies further support these findings. A nested case-control study based on serum drawn from a cohort of 25,620 individuals reported that moderately elevated concentrations of 25-hydroxyvitamin D, in the range 65-100 nmol/L, were associated with large reductions (P less than 0.05) in the incidence of colorectal cancer.
Calcium and vitamin D. Their potential roles in colon and breast cancer prevention. Garland CF, Garland FC, Gorham ED. Ann N Y Acad Sci. 1999;889:107-19. Department of Family and Preventive Medicine, University of California, San Diego 92093, USA. cgarland@ucsd.edu The geographic distribution of colon cancer is similar to the historical geographic distribution of rickets. The highest death rates from colon cancer occur in areas that had high prevalence rates of rickets--regions with winter ultraviolet radiation deficiency, generally due to a combination of high or moderately high latitude, high-sulfur content air pollution (acid haze), higher than average stratospheric ozone thickness, and persistently thick winter cloud cover. The geographic distribution of colon cancer mortality rates reveals significantly low death rates at low latitudes in the United States and significantly high rates in the industrialized Northeast. The Northeast has a combination of latitude, climate, and air pollution that prevents any synthesis of vitamin D during a five-month vitamin D winter. Breast cancer death rates in white women also rise with distance from the equator and are highest in areas with long vitamin D winters. Colon cancer incidence rates also have been shown to be inversely proportional to intake of calcium. These findings, which are consistent with laboratory results, indicate that most cases of colon cancer may be prevented with regular intake of calcium in the range of 1,800 mg per day, in a dietary context that includes 800 IU per day (20 micrograms) of vitamin D3. (In women, an intake of approximately 1,000 mg of calcium per 1,000 kcal of energy with 800 IU of vitamin D would be sufficient.) In observational studies, the source of approximately 90% of the calcium intake was vitamin D-fortified milk. Vitamin D may also be obtained from fatty fish. In addition to reduction of incidence and mortality rates from colon cancer, epidemiological data suggest that intake of 800 IU/day of vitamin D may be associated with enhanced survival rates among breast cancer cases. The association of calcium and vitamin D, and colon and rectal cancer in Wisconsin women. Marcus PM, Newcomb PA. Int J Epidemiol. 1998 Oct;27(5):788-93. University of Wisconsin Comprehensive Cancer Center, Madison 53792, USA. BACKGROUND: Calcium and vitamin D have been hypothesized to reduce colorectal cancer risk. Epidemiological evidence, however, is mixed. METHODS: To explore those relationships, data were collected as part of a population-based, case-control study of colorectal cancer in Wisconsin women (678 controls, 348 colon and 164 rectal cancer cases). A semi-quantitative food frequency questionnaire was used to ascertain food and dietary supplement intake 2 years prior to interview. Logistic regression models were used to calculate odds ratios (OR). RESULTS: Higher levels of calcium intake were associated with reduced colon and rectal cancer risk. The following adjusted OR and 95% confidence intervals (CI) were observed, comparing the fifth quintile (based on control intake) with the first: colon cancer: OR = 0.6, 95% CI: 0.4-1.0, P-trend: 0.03; rectal cancer: OR = 0.6, 95% CI: 0.3-1.1, P-trend: 0.07. Similar relationships were observed for vitamin D intake, although OR were closer to the null value and did not always behave in a step-wise fashion (fifth quintile versus the first--colon cancer: OR = 0.7, 95% CI: 0.4-1.1, P-trend: 0.05; rectal cancer: OR = 0.8, 95% CI: 0.5-1.5, P-trend: 0.42). CONCLUSION: These data support a protective association of calcium on colon and rectal cancer risk.
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*Caution: For any suspected or known illness or dysfunction, always consult your physician for medical diagnosis and treatment first. Statements contained herein have not been evaluated by the Food and Drug Administration. Products mentioned herein are not intended to diagnose, treat, cure, or prevent any disease. Before starting any nutritional supplementation consult your physician first. *This information is a collection of minerals and dietary supplements that are believed to be deficient in the body that promote the development of conditions that are unhealthy and take away from a natural healthy state. These statements have not been evaluated by the Food and Drug Administration. These products do not intended to diagnose, treat, cure, or prevent any disease. The information has been compiled from the information provided by those who have been helped from extensive research and experience. The information contained herein is not medical advice and is not intended to replace the advice or attention of health care professionals. Nor is this information intended to act as a "prescription" for treatment. These are ONLY suggestive guidelines for dietary supplements that may supplement the body's nutritional requirements to maintain optimum health. We advise consulting your health care provider before beginning any new dietary supplement program.
*The
information on this site is for educational purposes only.
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